Immunomodulatory effectiveness of azithromycin in prevention of postlaminectomy epidural fibrosis

Emmez H., BÖRCEK A. Ö., Durdag E., Uyar P. G., Kaymaz M., Aykol S.

NEUROLOGICAL RESEARCH, vol.33, no.4, pp.344-348, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.1179/016164110x12767786356471
  • Journal Name: NEUROLOGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.344-348
  • Keywords: Failed back syndrome, Peridural fibrosis, Macrolides, Azithromycin, PERIDURAL FIBROSIS, MITOMYCIN-C, SCAR FORMATION, EXPANDED POLYTETRAFLUOROETHYLENE, MACROLIDE ANTIBIOTICS, GAMMA-INTERFERON, SPINAL SURGERY, MESSENGER-RNA, LAMINECTOMY, MEMBRANE
  • Gazi University Affiliated: Yes

Abstract

Objective: One of the important causes of failed back surgery is the extensive peridural fibrosis collecting in the surgical field after spinal surgeries. Today we know that inflammatory mechanisms mediated by the immune system of the body plays an important role in generation of fibrosis. Azithromycin, a macrolide antibiotic, has proven immunomodulatory effects in various diseases. This study aims to investigate the effects of azithromycin on peridural fibrosis