Potential genetic biomarkers in the early diagnosis of Alzheimer disease: APOE and BIN1


Kaya G., Gunduz E., Acar M., Hatipoglu O. F. , Acar B., Ilhan A., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, sa.5, ss.1058-1072, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 45 Konu: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1405-96
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Sayfa Sayıları: ss.1058-1072

Özet

Background/aim: Alzheimer disease (AD) is triggered by interactions of multiple genetic and environmental factors. The APOE gene E4 allele is the best-known risk factor for AD, yet it represents a small ratio of genetic factors. According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene. We aimed to identify a novel biomarker indicating susceptibility to AD by investigating APOE alleles and BIN1 gene polymorphisms in a Turkish population.