Atıf İçin Kopyala
Kaya G., Gunduz E., Acar M., Hatipoglu O. F., Acar B., Ilhan A., ...Daha Fazla
TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, sa.5, ss.1058-1072, 2015 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
45
Sayı:
5
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Basım Tarihi:
2015
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Doi Numarası:
10.3906/sag-1405-96
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Dergi Adı:
TURKISH JOURNAL OF MEDICAL SCIENCES
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
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Sayfa Sayıları:
ss.1058-1072
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Anahtar Kelimeler:
Alzheimer disease, APOE, BIN1, polymorphism, biomarker, RFLP, APOLIPOPROTEIN-E POLYMORPHISM, ALLELE FREQUENCY, ASSOCIATION, ONSET, RISK, TAU, APOE-EPSILON-4, POPULATION, EXPRESSION, EPSILON-4
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Gazi Üniversitesi Adresli:
Evet
Özet
Background/aim: Alzheimer disease (AD) is triggered by interactions of multiple genetic and environmental factors. The APOE gene E4 allele is the best-known risk factor for AD, yet it represents a small ratio of genetic factors. According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene. We aimed to identify a novel biomarker indicating susceptibility to AD by investigating APOE alleles and BIN1 gene polymorphisms in a Turkish population.