Potential genetic biomarkers in the early diagnosis of Alzheimer disease: APOE and BIN1

Kaya G., Gunduz E., Acar M., Hatipoglu O. F., Acar B., Ilhan A., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.5, pp.1058-1072, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1405-96
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1058-1072
  • Keywords: Alzheimer disease, APOE, BIN1, polymorphism, biomarker, RFLP, APOLIPOPROTEIN-E POLYMORPHISM, ALLELE FREQUENCY, ASSOCIATION, ONSET, RISK, TAU, APOE-EPSILON-4, POPULATION, EXPRESSION, EPSILON-4
  • Gazi University Affiliated: Yes

Abstract

Background/aim: Alzheimer disease (AD) is triggered by interactions of multiple genetic and environmental factors. The APOE gene E4 allele is the best-known risk factor for AD, yet it represents a small ratio of genetic factors. According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene. We aimed to identify a novel biomarker indicating susceptibility to AD by investigating APOE alleles and BIN1 gene polymorphisms in a Turkish population.