TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.5, pp.1058-1072, 2015 (SCI-Expanded)
Article / Article
TURKISH JOURNAL OF MEDICAL SCIENCES
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Alzheimer disease, APOE, BIN1, polymorphism, biomarker, RFLP, APOLIPOPROTEIN-E POLYMORPHISM, ALLELE FREQUENCY, ASSOCIATION, ONSET, RISK, TAU, APOE-EPSILON-4, POPULATION, EXPRESSION, EPSILON-4
Gazi University Affiliated:
Background/aim: Alzheimer disease (AD) is triggered by interactions of multiple genetic and environmental factors. The APOE gene E4 allele is the best-known risk factor for AD, yet it represents a small ratio of genetic factors. According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene. We aimed to identify a novel biomarker indicating susceptibility to AD by investigating APOE alleles and BIN1 gene polymorphisms in a Turkish population.