Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis


Yeter H., Korucu B., Bali E. B. , Derici Ü.

International Journal For Vitamin And Nutrition Research, cilt.1, sa.8, ss.1-8, 2020 (SCI Expanded İndekslerine Giren Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1 Konu: 8
  • Basım Tarihi: 2020
  • Dergi Adı: International Journal For Vitamin And Nutrition Research
  • Sayfa Sayıları: ss.1-8

Özet

Abstract: Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are

associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D

analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a

minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were

excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were

analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in

patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative

stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D

preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index

were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of

active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is

as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.