The hidden phenomenon of oxidative stress during treatment of subclinical-mild hypothyroidism: A protective nutraceutical intervention

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Tomella C., Catanzaro R., Illuzzi N., Cabeca A., Zerbinati N., Celep G., ...More

Rejuvenation Research, vol.17, no.2, pp.180-183, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1089/rej.2013.1495
  • Journal Name: Rejuvenation Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.180-183
  • Gazi University Affiliated: Yes


Recent studies suggest that subjects with hypothyroidism under therapy with levothyroxine (L-T4) might develop oxidative stress. The aim of this study was to test a redox-balance modulator, fermented papaya-based nutraceutical (FPP), together with subclinical (SH) or mild hypothyroidism (MH) treatment in view of biochemical changes. A total of 60 females treated for SH-MH were divided into two matched groups and received either FPP 3 grams 1 sachet three times a day (t.i.d.) or placebo for 3 months. A significant baseline increase of all oxidative markers was observed in SH-MH (p<0.05vs. control) and even more under T4 treatment (p<0.05). FPP caused a normalization of redox markers (p<0.01vs. placebo). Thyroid supplementation accelerates mitochondrial oxygen consumption and oxidative stress, whereas a redox-modulator therapy is advisable, given the long-lasting treatment in such cases. © Copyright 2014, Mary Ann Liebert, Inc. 2014.