Serum biomarkers and non-invasive indices for discriminating MASLD among adults with dysglycaemia
Open Medicine (Poland), cilt.21, sa.1, ss.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1515/med-2026-1556
- Dergi Adı: Open Medicine (Poland)
- Derginin Tarandığı İndeksler: Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Scopus, Pharma Collection (ProQuest), Science Citation Index Expanded (SCI-EXPANDED), EMBASE, Directory of Open Access Journals
- Sayfa Sayıları: ss.1
- Gazi Üniversitesi Adresli: Evet
Özet
Objectives: Metabolic dysfunction–associated steatotic
liver disease (MASLD) is the most prevalent chronic liver
disease worldwide. Although dysglycaemia is a major risk
factor, additional cardiometabolic disturbances contribute
to the development of MASLD. This study aimed to identify
parameters that distinguish MASLD among dysglycaemic
individuals using body composition, anthropometric,
biochemical, and imaging-based assessments.
Methods: In this cross-sectional study, male and female
adults were stratified into three groups: dysglycaemic in-
dividuals with MASLD (MASLD-Dys), dysglycaemic in-
dividuals without MASLD (Dys), and normoglycaemic
individuals without MASLD as healthy controls. Imaging-
based hepatic fat quantification, body composition, anthro-
pometric and biochemical parameters, and non-invasive
indices assessing hepatic steatosis and fibrosis were
evaluated.
Results: Compared with Dys participants, MASLD-Dys par-
ticipants had higher body mass index (BMI), waist circum-
ference, trunk fat mass, ultrasound-derived hepatic fat
fraction (USFF), and Fatty Liver Index (FLI). The strongest
between-group separation was observed for USFF (p<0.001).
In receiver operating characteristic analysis, USFF showed
the highest discriminative performance for MASLD-Dys vs.
Dys, with an area under the curve of 0.925 and an optimal
cut-off of ≥6.95 %.
Conclusions: USFF was the strongest discriminator of
MASLD among dysglycaemic adults, while FLI provided a
practical non-imaging alternative. These findings support
integrating hepatic fat quantification and body composition
measures into MASLD risk stratification beyond glycaemic
status alone.
Keywords: dysglycaemia; body composition; Ultrasound-
derived Hepatic Fat Fraction (USFF); visceral adiposity