Utilizing Deep Convolutional Generative Adversarial Networks for Automatic Segmentation of Gliomas: An Artificial Intelligence Study

Aydogan Duman E., SAĞIROĞLU Ş., Celtikci P., Demirezen M. U., BÖRCEK A. Ö., Emmez H., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.32, sa.1, ss.16-21, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5137/1019-5149.jtn.29217-20.2
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.16-21
  • Anahtar Kelimeler: Artificial intelligence, Deep learning, Glioma, Machine learning, Segmentation, BRAIN IMAGES, RADIOGENOMICS, SURVIVAL
  • Gazi Üniversitesi Adresli: Evet

Özet

AIM: To describe a deep convolutional generative adversarial networks (DCGAN) model which learns normal brain MRI from normal subjects than finds distortions such as a glioma from a test subject while performing a segmentation at the same time. MATERIAL and METHODS: MRIs of 300 healthy subjects were employed as training set. Additionally, test data were consisting anonymized T2-weigted MRIs of 27 healthy subjects and 27 HGG patients. Consecutive axial T2-weigted MRI slices of every subject were extracted and resized to 364x448 pixel resolution. The generative model produced random normal synthetic images and used these images for calculating residual loss to measure visual similarity between input MRIs and generated MRIs. RESULTS: The model correctly detected anomalies on 24 of 27 HGG patients' MRIs and marked them as abnormal. Besides, 25 of 27 healthy subjects' MRIs in the test dataset detected correctly as healthy MRI. The accuracy, precision, recall, and AUC were 0.907, 0.892, 0.923, and 0.907, respectively. CONCLUSION: Our proposed model demonstrates acceptable results can be achieved only by training with normal subject MRIs via using DCGAN model. This model is unique because it learns only from normal MRIs and it is able to find any abnormality which is different than the normal pattern.