Memory-vitalizing effect of twenty-five medicinal and edible plants and their isolated compounds

ŞENOL DENİZ F. S., ERDOĞAN ORHAN İ., ÖZGEN U., RENDA G., Bulut G., GÜVEN L., ...Daha Fazla

SOUTH AFRICAN JOURNAL OF BOTANY, cilt.102, ss.102-109, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 102
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.sajb.2015.07.011
  • Dergi Adı: SOUTH AFRICAN JOURNAL OF BOTANY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.102-109
  • Anahtar Kelimeler: Cholinesterase, Tyrosinase, Enzyme inhibition, Antioxidant, Extract, Screening, ST JOHNS WORT, ANTIOXIDANT ACTIVITIES, ACETYLCHOLINESTERASE, ANTICHOLINESTERASE, BUTYRYLCHOLINESTERASE, CHOLINESTERASE, L., EXTRACTS, ENZYMES
  • Gazi Üniversitesi Adresli: Evet

Özet

The extracts from 25 plant species from Salvia, Hypericum, Onosma, Thymus, Origanum, Rosa, and Prunus with eight isolated compounds were screened for their memory-vitalizing potential against the enzymes, i.e., acetyl cholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase (TYR) along with DPPH, DMPD, and NO radicals and iron-chelation capacity using spectrophotometric microtiter assays. The n-hexane:dichloromethane (1:1) extract of Onosma nigricaule roots (63.18 +/- 0.56%) and the ethyl acetate extract of the aerial parts of Hypericum capitatum var. capitatum (50.79 +/- 3.88%) were the most active toward AChE and BChE, respectively. The highest iron-chelating capacity was found in the n-hexane extract of Thymus sipyleus subsp. sipyleus var. sipyleus, where mostly Labiatae species exhibited better radical scavenging effect. Among the extracts, the roots of O. nigricaule, the aerial parts of Hypericum capitatum var. capitatum and T. sipyleus subsp. sipyleus var. sipyleus could be further evaluated for their memory-vitalizing properties based on different mechanisms. (C) 2015 SAAB. Published by Elsevier B.V. All rights reserved.