Factors affecting live birth rate in intrauterine insemination cycles with recombinant gonadotrophin stimulation

ERDEM O. A., Erdern M., Atmaca S., Korucuoglu U., KARABACAK R. O.

REPRODUCTIVE BIOMEDICINE ONLINE, vol.17, no.2, pp.199-206, 2008 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.1016/s1472-6483(10)60195-2
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.199-206
  • Keywords: clinical pregnancy, intrauterine insemination, live birth rate, male factor, rccombinant gonadotrophins, unexplained subfertility, CONTROLLED OVARIAN HYPERSTIMULATION, HUMAN MENOPAUSAL GONADOTROPIN, IN-VITRO FERTILIZATION, CLOMIPHENE CITRATE, PREGNANCY RATES, ONGOING PREGNANCY, SPERM QUALITY, INFERTILITY, EFFICACY, AGE
  • Gazi University Affiliated: Yes


The objective of this cross-sectional study was to identify the prognostic factors that influence the outcome of ovarian stimulation with intrauterine insemination (IUI) cycles using gonaclotrophins in couples with unexplained and mild trialefactor subfertility. A total of 838 cycles in 456 women wi th unexplained and inild male-factor subfertility attencling a University-based infertility clinic was evaluated. Of these cycles, 139 resulted in pregnancy (16.6% per cycle) and 96 out of 98 ongoing pregnancies resulted in live term birth. Live birth rate per patient and per cycle was 21.1% and 11.4%. respective ly. Multivariate logistic regression analysis demonstrated that duration of infertility (P = 0.034), type of infertility (P = 0.003), aetiology of infertility (P = 0.004), number of treatment cycles (P = 0.000 1) and number of dominant follicles before human chorionic gonaclotrophin (HCG; P = 0.024) were significant independent factors to predict clinical pregnancy. The duration of infertility (P = 0.043), number of treatment cycles (P = 0.0001) and]lumber of dominant follicles before HCG (P = 0.024) were significant independent factors to predict live birth. In conclusion, for subfertile couples having shorter duration Of Albfertility, inultifollicular response to gonadotrophins and in their first treatment cycle are more likely to Succeed a live birth with IU1 treatment using recombinant gonadotrophins.