The protonation equilibria of selected glycine dipeptides in ethanol-water mixture: solvent composition effect

Dogan A., ÖZEL A. D., KILIÇ E.

AMINO ACIDS, cilt.36, sa.2, ss.373-379, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s00726-008-0054-5
  • Dergi Adı: AMINO ACIDS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.373-379
  • Anahtar Kelimeler: Dipeptides, Protonation constants, Ethanol-water mixture, Potentiometry, ALPHA-AMINO-ACIDS, METAL-PEPTIDE COMPLEXES, COPPER(II) COMPLEXES, PREFERENTIAL SOLVATION, STABILITY-CONSTANTS, SOLID-STATE, THERMODYNAMICS, NICKEL(II), HYDROGEN, SYSTEMS
  • Gazi Üniversitesi Adresli: Evet

Özet

Knowledge of the protonation constants of small dipeptide is important, interesting and necessary for complete understanding of the physiochemical behavior of dipeptide. In this study, the protonation constants of some aliphatic dipeptides (Gly-Gly, Gly-Val, Gly-Leu, Gly-Thr, Gly-Phe and Gly-Met) were studied in water and ethanol-water mixtures [20% ethanol-80% water, 40% ethanol-60% water, 60% ethanol-40% water, (v/v)] at 25 +/- A 0.1A degrees C under nitrogen atmosphere and ionic strength at 0.10 mol dm(-3) by potentiometry. The constants of the systems were calculated by using BEST computer program, and distribution species diagrams were produced using the SPE computer program. The protonation constants were influenced by changes in solvent composition, and their variations were discussed in terms of solvent and structural properties. The concentration distribution of the various species in ethanol-water mixtures was evaluated.