Administration of Ginkgo biloba Extract (EGb761) Alone and in Combination with FK506 Promotes Liver Regeneration in a Rat Model of Partial Hepatectomy


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Gunay N. E. , MUHTAROĞLU S., BEDİRLİ A.

BALKAN MEDICAL JOURNAL, vol.35, no.2, pp.174-180, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.4274/balkanmedj.2016.1830
  • Journal Name: BALKAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.174-180
  • Keywords: EGb761, FK506, hepatectomy, liver, oxidative stress, regeneration, thymidine kinase, mitosis, HEPATIC-INJURY, REPERFUSION, ISCHEMIA, EGB-761, ASSAY
  • Gazi University Affiliated: Yes

Abstract

Background: Free radical damage is known to occur during liver regeneration. The Ginkgo biloba extract EGb761 has antioxidant properties due to its ability to scavenge free radicals. FK506 has been widely used as an immunosuppressant that stimulates hepatocyte proliferation following partial hepatectomy.