Administration of Ginkgo biloba Extract (EGb761) Alone and in Combination with FK506 Promotes Liver Regeneration in a Rat Model of Partial Hepatectomy

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Gunay N. E., MUHTAROĞLU S., BEDİRLİ A.

BALKAN MEDICAL JOURNAL, cilt.35, sa.2, ss.174-180, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4274/balkanmedj.2016.1830
  • Dergi Adı: BALKAN MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.174-180
  • Anahtar Kelimeler: EGb761, FK506, hepatectomy, liver, oxidative stress, regeneration, thymidine kinase, mitosis, HEPATIC-INJURY, REPERFUSION, ISCHEMIA, EGB-761, ASSAY
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Free radical damage is known to occur during liver regeneration. The Ginkgo biloba extract EGb761 has antioxidant properties due to its ability to scavenge free radicals. FK506 has been widely used as an immunosuppressant that stimulates hepatocyte proliferation following partial hepatectomy.