Anti-apoptotic and neuroprotective effects of alpha-lipoic acid on spinal cord ischemia-reperfusion injury in rabbits

Emmez H., Yildirim Z., KALE A., Tonge M., Durdag E., BÖRCEK A. Ö., ...Daha Fazla

ACTA NEUROCHIRURGICA, cilt.152, sa.9, ss.1591-1601, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 152 Sayı: 9
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s00701-010-0703-9
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1591-1601
  • Anahtar Kelimeler: Spinal cord injury, Ischemia-reperfusion injury, Lipid peroxidation, Lipoic acid, EARLY ULTRASTRUCTURAL FINDINGS, FOCAL CEREBRAL-ISCHEMIA, NERVOUS-SYSTEM ISCHEMIA, FREE-RADICAL SCAVENGER, LIPID-PEROXIDATION, OXIDATIVE STRESS, NITRIC-OXIDE, ANTIOXIDANT DEFENSE, ESTROGEN-RECEPTOR, SECONDARY DAMAGE
  • Gazi Üniversitesi Adresli: Evet

Özet

Radical oxygen species produced after injury counteracts antioxidant activity and frequently causes severe oxidative stress for the tissues. Alpha-lipoic acid is a powerful metabolic antioxidant with immunomodulatory effects which provides neuroprotection. The aim of this study is to investigate the neuroprotective and anti-apoptotic effects of alpha-lipoic acid on spinal cord ischemia-reperfusion.