Anti-apoptotic and neuroprotective effects of alpha-lipoic acid on spinal cord ischemia-reperfusion injury in rabbits

Emmez H., Yildirim Z., KALE A. , Tonge M., Durdag E., BÖRCEK A. Ö. , ...Daha Fazla

ACTA NEUROCHIRURGICA, cilt.152, sa.9, ss.1591-1601, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 152 Konu: 9
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s00701-010-0703-9
  • Sayfa Sayıları: ss.1591-1601


Radical oxygen species produced after injury counteracts antioxidant activity and frequently causes severe oxidative stress for the tissues. Alpha-lipoic acid is a powerful metabolic antioxidant with immunomodulatory effects which provides neuroprotection. The aim of this study is to investigate the neuroprotective and anti-apoptotic effects of alpha-lipoic acid on spinal cord ischemia-reperfusion.