Anti-apoptotic and neuroprotective effects of alpha-lipoic acid on spinal cord ischemia-reperfusion injury in rabbits
ACTA NEUROCHIRURGICA, cilt.152, sa.9, ss.1591-1601, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 152 Sayı: 9
- Basım Tarihi: 2010
- Doi Numarası: 10.1007/s00701-010-0703-9
- Dergi Adı: ACTA NEUROCHIRURGICA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1591-1601
- Anahtar Kelimeler: Spinal cord injury, Ischemia-reperfusion injury, Lipid peroxidation, Lipoic acid, EARLY ULTRASTRUCTURAL FINDINGS, FOCAL CEREBRAL-ISCHEMIA, NERVOUS-SYSTEM ISCHEMIA, FREE-RADICAL SCAVENGER, LIPID-PEROXIDATION, OXIDATIVE STRESS, NITRIC-OXIDE, ANTIOXIDANT DEFENSE, ESTROGEN-RECEPTOR, SECONDARY DAMAGE
- Gazi Üniversitesi Adresli: Evet
Özet
Radical oxygen species produced after injury counteracts antioxidant activity and frequently causes severe oxidative stress for the tissues. Alpha-lipoic acid is a powerful metabolic antioxidant with immunomodulatory effects which provides neuroprotection. The aim of this study is to investigate the neuroprotective and anti-apoptotic effects of alpha-lipoic acid on spinal cord ischemia-reperfusion.