Hypoxia inducible factor-1 alpha and carbonic anhydrase IX overexpression are associated with poor survival in breast cancer patients

Kaya A. O. , Gunel N., Benekli M., Akyurek N., Buyukberber S., Tatli H., ...Daha Fazla

JOURNAL OF BUON, cilt.17, sa.4, ss.663-668, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Konu: 4
  • Basım Tarihi: 2012
  • Dergi Adı: JOURNAL OF BUON
  • Sayfa Sayıları: ss.663-668


Purpose: Hypoxia is common in many solid tumors such as breast, head-neck, and soft tissue malignancies. Hypoxia causes overexpression of hypoxia inducible factor-1 alpha (HIF-1 alpha) and carbonic anhydrase IX (CA IX) which are associated with unfavorable prognosis in breast cancer. In our study, we evaluated HIF-1 alpha and CA IX expression in patients with breast cancer.