Hypoxia inducible factor-1 alpha and carbonic anhydrase IX overexpression are associated with poor survival in breast cancer patients

Kaya A. O., Gunel N., Benekli M., Akyurek N., Buyukberber S., Tatli H., ...Daha Fazla

JOURNAL OF BUON, cilt.17, sa.4, ss.663-668, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 4
  • Basım Tarihi: 2012
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.663-668
  • Anahtar Kelimeler: breast cancer, tumor hypoxia, HIF-1 alpha, CA IX, prognosis, PROGNOSTIC MARKER, FOLLOW-UP, CA-IX, FACTOR-1-ALPHA, EXPRESSION, RADIOTHERAPY, CELLS
  • Gazi Üniversitesi Adresli: Evet

Özet

Purpose: Hypoxia is common in many solid tumors such as breast, head-neck, and soft tissue malignancies. Hypoxia causes overexpression of hypoxia inducible factor-1 alpha (HIF-1 alpha) and carbonic anhydrase IX (CA IX) which are associated with unfavorable prognosis in breast cancer. In our study, we evaluated HIF-1 alpha and CA IX expression in patients with breast cancer.