Hypoxia inducible factor-1 alpha and carbonic anhydrase IX overexpression are associated with poor survival in breast cancer patients

Kaya A. O., Gunel N., Benekli M., Akyurek N., Buyukberber S., Tatli H., ...More

JOURNAL OF BUON, vol.17, no.4, pp.663-668, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 4
  • Publication Date: 2012
  • Journal Name: JOURNAL OF BUON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.663-668
  • Keywords: breast cancer, tumor hypoxia, HIF-1 alpha, CA IX, prognosis, PROGNOSTIC MARKER, FOLLOW-UP, CA-IX, FACTOR-1-ALPHA, EXPRESSION, RADIOTHERAPY, CELLS
  • Gazi University Affiliated: Yes

Abstract

Purpose: Hypoxia is common in many solid tumors such as breast, head-neck, and soft tissue malignancies. Hypoxia causes overexpression of hypoxia inducible factor-1 alpha (HIF-1 alpha) and carbonic anhydrase IX (CA IX) which are associated with unfavorable prognosis in breast cancer. In our study, we evaluated HIF-1 alpha and CA IX expression in patients with breast cancer.