Hypoxia inducible factor-1 alpha and carbonic anhydrase IX overexpression are associated with poor survival in breast cancer patients

Kaya, A.; Gunel, N.; Benekli, M.; Akyurek, N.; Buyukberber, S.; Tatli, H.; Coskun, UĞUR; Yildiz, R.; Yaman, E.; Ozturk, B.

Hypoxia inducible factor-1 alpha and carbonic anhydrase IX overexpression are associated with poor survival in breast cancer patients

Kaya A. O., Gunel N., Benekli M., Akyurek N., Buyukberber S., Tatli H., ...Daha Fazla

JOURNAL OF BUON, cilt.17, sa.4, ss.663-668, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 17 Sayı: 4
Basım Tarihi: 2012
Dergi Adı: JOURNAL OF BUON
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.663-668
Anahtar Kelimeler: breast cancer, tumor hypoxia, HIF-1 alpha, CA IX, prognosis, PROGNOSTIC MARKER, FOLLOW-UP, CA-IX, FACTOR-1-ALPHA, EXPRESSION, RADIOTHERAPY, CELLS
Gazi Üniversitesi Adresli: Evet

Özet

Purpose: Hypoxia is common in many solid tumors such as breast, head-neck, and soft tissue malignancies. Hypoxia causes overexpression of hypoxia inducible factor-1 alpha (HIF-1 alpha) and carbonic anhydrase IX (CA IX) which are associated with unfavorable prognosis in breast cancer. In our study, we evaluated HIF-1 alpha and CA IX expression in patients with breast cancer.