Evaluation of Tryptophan Metabolism in Chronic Immune Activation


ENGİN A. B.

TRYPTOPHAN METABOLISM: IMPLICATIONS FOR BIOLOGICAL PROCESSES, HEALTH AND DISEASE, pp.121-145, 2015 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Publication Date: 2015
  • Doi Number: 10.1007/978-3-319-15630-9_6
  • Journal Name: TRYPTOPHAN METABOLISM: IMPLICATIONS FOR BIOLOGICAL PROCESSES, HEALTH AND DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.121-145
  • Keywords: Tryptophan, Kynurenine, Neopterin, Ulcerative colitis, Crohn's disease, Irritable bowel syndrome, Immune escape mechanisms, Obesity, Aging, IRRITABLE-BOWEL-SYNDROME, REGULATORY T-CELLS, INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY, ARYLALKYLAMINE N-ACETYLTRANSFERASE, PLASMACYTOID DENDRITIC CELLS, EXCESSIVE L-TRYPTOPHAN, TOLL-LIKE RECEPTORS, INTERFERON-GAMMA, 3-HYDROXYANTHRANILIC ACID, SEROTONIN TRANSPORTER
  • Gazi University Affiliated: Yes

Abstract

Chronic immune activation is encountered in different pathologies including granulomatous and functional bowel diseases, cancer, aging, atherosclerosis, and obesity. Persistence of chronic inflammatory stimuli over time creates a biologic background for immunosenescence and favors neopterin formation with the enhanced tryptophan (Trp) degradation in diseases concomitant with cellular immune activation. Trp degradation leads to the generation of several neuroactive compounds by three distinct pathways.