Evaluation of Tryptophan Metabolism in Chronic Immune Activation

ENGİN A. B.

TRYPTOPHAN METABOLISM: IMPLICATIONS FOR BIOLOGICAL PROCESSES, HEALTH AND DISEASE, ss.121-145, 2015 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/978-3-319-15630-9_6
  • Dergi Adı: TRYPTOPHAN METABOLISM: IMPLICATIONS FOR BIOLOGICAL PROCESSES, HEALTH AND DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.121-145
  • Anahtar Kelimeler: Tryptophan, Kynurenine, Neopterin, Ulcerative colitis, Crohn's disease, Irritable bowel syndrome, Immune escape mechanisms, Obesity, Aging, IRRITABLE-BOWEL-SYNDROME, REGULATORY T-CELLS, INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY, ARYLALKYLAMINE N-ACETYLTRANSFERASE, PLASMACYTOID DENDRITIC CELLS, EXCESSIVE L-TRYPTOPHAN, TOLL-LIKE RECEPTORS, INTERFERON-GAMMA, 3-HYDROXYANTHRANILIC ACID, SEROTONIN TRANSPORTER
  • Gazi Üniversitesi Adresli: Evet

Özet

Chronic immune activation is encountered in different pathologies including granulomatous and functional bowel diseases, cancer, aging, atherosclerosis, and obesity. Persistence of chronic inflammatory stimuli over time creates a biologic background for immunosenescence and favors neopterin formation with the enhanced tryptophan (Trp) degradation in diseases concomitant with cellular immune activation. Trp degradation leads to the generation of several neuroactive compounds by three distinct pathways.