TRYPTOPHAN METABOLISM: IMPLICATIONS FOR BIOLOGICAL PROCESSES, HEALTH AND DISEASE, pp.121-145, 2015 (SCI-Expanded)
Article / Article
TRYPTOPHAN METABOLISM: IMPLICATIONS FOR BIOLOGICAL PROCESSES, HEALTH AND DISEASE
Science Citation Index Expanded (SCI-EXPANDED)
Tryptophan, Kynurenine, Neopterin, Ulcerative colitis, Crohn's disease, Irritable bowel syndrome, Immune escape mechanisms, Obesity, Aging, IRRITABLE-BOWEL-SYNDROME, REGULATORY T-CELLS, INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY, ARYLALKYLAMINE N-ACETYLTRANSFERASE, PLASMACYTOID DENDRITIC CELLS, EXCESSIVE L-TRYPTOPHAN, TOLL-LIKE RECEPTORS, INTERFERON-GAMMA, 3-HYDROXYANTHRANILIC ACID, SEROTONIN TRANSPORTER
Gazi University Affiliated:
Chronic immune activation is encountered in different pathologies including granulomatous and functional bowel diseases, cancer, aging, atherosclerosis, and obesity. Persistence of chronic inflammatory stimuli over time creates a biologic background for immunosenescence and favors neopterin formation with the enhanced tryptophan (Trp) degradation in diseases concomitant with cellular immune activation. Trp degradation leads to the generation of several neuroactive compounds by three distinct pathways.