Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature


GÜLTEKİN S. E. , Senguven B., IŞIK GÖNÜL İ. , Okur B., Buettner R.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, vol.74, no.10, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 74 Issue: 10
  • Publication Date: 2016
  • Doi Number: 10.1016/j.joms.2016.06.004
  • Title of Journal : JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Abstract

Lung cancer is the most frequent cause of cancer-related death worldwide. Metastases of non-small cell lung carcinoma to the oral and maxillofacial region are rare. Thus, the diagnosis of a metastatic lesion in the oral cavity is challenging to the clinician and to the pathologist. This report presents a case of a 72-year-old man with metastatic lung adenocarcinoma located in the posterior mandibular region. Next-generation sequencing analysis showed no important mutations in the relevant genes except in the TP53 tumor suppressor gene. (C) 2016 American Association of Oral and Maxillofacial Surgeons