Demonstration of Mutation Development and Virulence Change in Reference Candida Strains Exposed to Caspofungin

BALTACI N., KALKANCI A.

Journal of Basic and Clinical Health Sciences, cilt.5, sa.2, ss.115-123, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.30621/jbachs.920675
  • Dergi Adı: Journal of Basic and Clinical Health Sciences
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.115-123
  • Anahtar Kelimeler: Candida, Caspofungin, FKS mutation, Galleria mellonella, virulence, IN-VITRO, FKS MUTATIONS, ALBICANS, GLABRATA, RESISTANCE, IMPACT
  • Gazi Üniversitesi Adresli: Evet

Özet

Purpose: Echinocandin resistance is causing problems in the treatment. FKS gene mutations were detected on the genomes of the resistant Candida strains exposed to echinocandins. The aim of this study was to compare the resistance of reference Candida strains exposed to caspofungin and to investigate whether there was a difference in virulence factors between exposed and non-exposed with caspofungin.