Endogenous neuropeptides in patients with acute traumatic head injury .1. Cerebrospinal fluid beta-endorphin levels are increased within 24 hours following the trauma

Pasaoglu H., Karakucuk E., Kurtsoy A., Pasaoglu A.

NEUROPEPTIDES, vol.30, no.1, pp.47-51, 1996 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 1
  • Publication Date: 1996
  • Journal Name: NEUROPEPTIDES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.47-51
  • Gazi University Affiliated: No


The changes in the cerebrospinal fluid (CSF) beta-endorphin (beta-end) levels within 24 h following the trauma were examined in 45 patients with head injuries. CSF samples obtained from 25 healthy subjects who had minor surgical operations under spinal anaesthesia were included as the controls. Patients with head injuries were evaluated according to their Glasgow Coma Scale (GCS) scores on admission to the neurosurgery clinic and four subgroups were formed as follows: Group I: minor head trauma (GCS: 13-15) without skull fracture; Group II: mild head injury (GCS: 13-15) with skull fracture; Group III: moderate head injury (GCS: 8-12) and Group IV: severe head injury (GCS: < 8).