Histiocytic sarcoma: PET-CT evaluation of a rare entity

Yaman E., Ozturk B., ERDEM O. A., Gokcora N., Coskun U., Uluoglu O., ...More

ANNALS OF NUCLEAR MEDICINE, vol.22, no.8, pp.715-717, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 8
  • Publication Date: 2008
  • Doi Number: 10.1007/s12149-008-0175-7
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.715-717
  • Keywords: Histiocytic sarcoma, PET-CT, Disseminated disease, EMISSION-TOMOGRAPHY, LYMPHOMA, TUMORS
  • Gazi University Affiliated: Yes


Histiocytic sarcoma is a rare malignancy of hematopoietic origin. Lymph nodes, skin, and extranodal sites, especially gastrointestinal tract, are commonly involved. Some cases reported in the past as non-Hodgkin's lymphoma are now classifi ed as histiocytic sarcoma by detailed immunohistochemical studies. Patients with clinically localized disease have a good prognosis whereas those with lymphatic involvement have an aggressive course. In our case, histiocytic sarcoma was detected, originating from the skin over the left shoulder associated with disseminated lymphadenopathy. A positron emission tomography/computed tomography examination was done for evaluating the extent of the disease which showed pathologic increased 18F-fl uorodeoxyglucose uptake in the lymph nodes, indicating widespread disease. The pertinent literature is reviewed.