Herbal Ingredients in the Prevention of Breast Cancer: Comprehensive Review of Potential Molecular Targets and Role of Natural Products


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Akkol E. K. , Bardakci H., Barak T. H. , Aschner M., Karatoprak G. S. , Khan H., ...More

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, vol.2022, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 2022
  • Publication Date: 2022
  • Doi Number: 10.1155/2022/6044640
  • Journal Name: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Compendex, EMBASE, MEDLINE, Directory of Open Access Journals
  • Gazi University Affiliated: Yes

Abstract

Among various cancers, breast cancer is the most prevalent type in women throughout the world. Breast cancer treatment is challenging due to complex nature of the etiology of disease. Cell division cycle alterations are often encountered in a variety of cancer types including breast cancer. Common treatments include chemotherapy, surgery, radiotherapy, and hormonal therapy; however, adverse effects and multidrug resistance lead to complications and noncompliance. Accordingly, there is an increasing demand for natural products from medicinal plants and foods. This review summarizes molecular mechanisms of signaling pathways in breast cancer and identifies mechanisms by which natural compounds may exert their efficacy in the treatment of breast cancer.