Museums are the places where the pieces of art are stored, exhibited and maintained. Even if precision air conditioning is demanded by museum experts to protect the pieces threatened by environmental impacts, the most appropriate engineering solution should be chosen for air conditioning taking into account energy saving, investment costs and operating costs. In this study, the works on air-conditioning in museums are evaluated and recommendations on what to care about while conducting air-conditioning works in museums are provided. It is very preferable to use a historic building as a museum building because the building itself can be considered as a piece. In such a case, while setting up an air-conditioning system that protects the works, it should be avoided that the historical museum building gets damaged. In this study, the air-conditioning and monitoring activities in the Museum of Anatolian Civilizations, which resides in an historical building, were examined. It was thought that it would be beneficial to ask for the B class conformity set by ASHRAE (American Society of Heating, Refrigerating and Air-Conditioning Engineers) for museums. In the measurements conducted previously, it was observed that the dry bulb temperature remained in the appropriate range between 16 °C and 27 °C and the relative humidity fluctuated between favorable conditions. In addition, recommendations were made on issues like system efficiency and energy efficiency.