Anti-Inflammatory and Antinociceptive Activity of Coumarins from Seseli gummiferum subsp corymbosum (Apiaceae)


TOSUN A., AKKOL E., YEŞİLADA E.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, vol.64, pp.56-62, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64
  • Publication Date: 2009
  • Doi Number: 10.1515/znc-2009-1-210
  • Journal Name: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.56-62
  • Keywords: Apiaceae, Anti-Inflammatory Activity, Antinociceptive Activity, ESSENTIAL OIL COMPOSITION, TURKEY, TORTUOSUM, EDEMA, MICE, CONSTITUENTS, UMBELLIFERAE, VAYREDANUM, RESINOSUM, ACID
  • Gazi University Affiliated: Yes

Abstract

n-Hexane and ethyl acetate extracts as well as coumarin derivatives obtained from the n-hexane extract of the aerial parts of Seseli gummiferum Pall. ex Sm. subsp. corymbosum (Boiss. & Heldr.) P.H. Davis (Apiaceae) were evaluated in vivo for their anti-inflammatory and antinociceptive activities. The n-hexane and ethyl acetate extracts of the species were shown to possess significant inhibitory activity against the carrageenan-induced hind paw edema and p-benzoquinone-induced writhing models in mice. Among the isolated coumarin derivatives; (-)-(3'S,4'S)-3'-acetoxy-4'-isovaleryloxy-3',4'-dihydroseselin (1), (-)-(3'S14 S)-3'-acetoxy-4'-angeloyloxy-3'.4'-dihydroseselin (2),(+)-(3'S,4'S)-3'-hydroxy-4'-angeloyloxy-3',4'dihydroseselin (D-laserpitin) (3), (-)-(3'S,4'S)-3'-angeloyloxy-4'-hydroxy-3',4'-dihydroseselin (4), and osthole (5), only the 3'-acetoxy derivatives 1 and 2 were found to possess potent antinociceptive and anti-inflammatory activities, per os, without inducing any apparent acute toxicity as well as gastric damage, while all other compounds and extracts were found to be ineffective in the TPA-induced mouse ear edema model assay.