Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system


Alpaslan C., Irie K., Takahashi K., Ohashi N., Sakai H., Nakajima T., ...Daha Fazla

BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, cilt.34, sa.5, ss.414-418, 1996 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Konu: 5
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1016/s0266-4356(96)90098-4
  • Dergi Adı: BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
  • Sayfa Sayıları: ss.414-418

Özet

The efficacy of microspheres made of polylactic acid polyglycolic acid copolymer mixed with blood clot as a delivery system for recombinant human bone morphogenetic protein-2 (rhBMP-2) was evaluated and the long term behaviour of rhBMP-2 in rats was studied. Twenty micro grams of rhBMP-2 in 200 mu l carrier (blood coagulum and polylactic acid polyglycolic acid porous microspheres) were implanted subcutaneously over both sides of the chest muscles in 40 5-week-old male Long Evans rats. The control group were implanted with carrier alone. Specimens were retrieved after 3 days and weekly for 9 weeks.