Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system

Alpaslan, CANSU; Irie, K; Takahashi, K; Ohashi, N; Sakai, H; Nakajima, T; Ozawa, H

doi:10.1016/s0266-4356(96)90098-4

Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system

Atıf İçin Kopyala

Alpaslan C., Irie K., Takahashi K., Ohashi N., Sakai H., Nakajima T., ...Daha Fazla

BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, cilt.34, sa.5, ss.414-418, 1996 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 34 Sayı: 5
Basım Tarihi: 1996
Doi Numarası: 10.1016/s0266-4356(96)90098-4
Dergi Adı: BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.414-418
Gazi Üniversitesi Adresli: Evet

Özet

The efficacy of microspheres made of polylactic acid polyglycolic acid copolymer mixed with blood clot as a delivery system for recombinant human bone morphogenetic protein-2 (rhBMP-2) was evaluated and the long term behaviour of rhBMP-2 in rats was studied. Twenty micro grams of rhBMP-2 in 200 mu l carrier (blood coagulum and polylactic acid polyglycolic acid porous microspheres) were implanted subcutaneously over both sides of the chest muscles in 40 5-week-old male Long Evans rats. The control group were implanted with carrier alone. Specimens were retrieved after 3 days and weekly for 9 weeks.