Pro-oxidative/antioxidative imbalance: a key indicator of adverse outcome in hematopoietic stem cell transplantation

Yegin, ZEYNEP; Pasaoglu, HATİCE; Aki, S.; Ozkurt, ZÜBEYDE; Demirtas, CANAN; Yagci, ABDULLAH; Acar, K.; Sucak, G.

doi:10.1111/j.1751-553x.2011.01297.x

Pro-oxidative/antioxidative imbalance: a key indicator of adverse outcome in hematopoietic stem cell transplantation

Yegin Z. A., Pasaoglu H., Aki S. Z., Ozkurt Z. N., Demirtas C., Yagci M., ...Daha Fazla

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, cilt.33, sa.4, ss.414-423, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 33 Sayı: 4
Basım Tarihi: 2011
Doi Numarası: 10.1111/j.1751-553x.2011.01297.x
Dergi Adı: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.414-423
Anahtar Kelimeler: Iron overload, oxidative stress, ferritin, nontransferrin bound iron, stem cell transplantation, BONE-MARROW-TRANSPLANTATION, TRANSFERRIN-BOUND IRON, PRETRANSPLANTATION SERUM FERRITIN, SINUSOIDAL OBSTRUCTION SYNDROME, LIVER DYSFUNCTION, PROGNOSTIC IMPACT, OXIDATIVE STRESS, RISK-FACTOR, OVERLOAD, RECIPIENTS
Gazi Üniversitesi Adresli: Evet

Özet

Introduction: Pretransplantation iron overload (IO) is considered as a predictor of adverse outcome in hematopoietic stem cell transplantation (HSCT). Peroxidative tissue injury caused by IO leads to progressive organ dysfunction.