Evaluation of biorelevant media to investigate the dissolution properties on flurbiprofen and to assess cytotoxicity effects on Caco-2 cell line

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Yasin D. S., Yilmaz S., TEKSİN Z. Ş.

ISTANBUL JOURNAL OF PHARMACY, cilt.48, sa.3, ss.82-88, 2018 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.26650/istanbuljpharm.2018.180013
  • Dergi Adı: ISTANBUL JOURNAL OF PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.82-88
  • Anahtar Kelimeler: Biorelevant media, flurbiprofen, cytotoxicity, IN-VIVO PERFORMANCE, INTESTINAL FLUIDS, VITRO DISSOLUTION, SOLUBILITY, ABSORPTION, DRUGS, CLASSIFICATION, HUMANS, SYSTEM, FOOD
  • Gazi Üniversitesi Adresli: Evet

Özet

Biorelevant media are used to simulate the physiological conditions in terms of components, pH, osmolality and buffer capacity of the human stomach and intestine in both fasted and fed states In this study, we aim to apply the biorelevant media to Caco-2 cell lines to investigate the cytotoxicity effects via the cell viability ratio and to compare the solubilizing effects of various dissolution media on a poorly soluble model drug. Flurbiprofen (Biopharmaceutics Classification System, BCS Class 2) was selected as a model drug.