Engineering of Stimuli-Sensitive Nanopreparations to Overcome Physiological Barriers and Cancer Multidrug Resistance

MUTLU AĞARDAN N. B., Torchilin V. P.

Engineering of Nanobiomaterials: Applications of Nanobiomaterials, Elsevier, ss.1-28, 2016 identifier

  • Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/b978-0-323-41532-3.00001-4
  • Yayınevi: Elsevier
  • Sayfa Sayıları: ss.1-28
  • Anahtar Kelimeler: Biological barriers, Cancer, Cellular barriers, Drug delivery, Multidrug resistance, Physiological barriers, Stimuli-sensitive nanopreparations, Tumor microenvironment
  • Gazi Üniversitesi Adresli: Evet

Özet

Cancer nanotechnology is an interdisciplinary area of research, whose main objective is delivery of therapeutic agents to tumors, that destroy cancer cells with minimum damage to normal cells. The advantages of nanopreparations such as liposomes, micelles, and polymeric nanoparticles over conventional therapies are well-established. Currently, research has been focused on further engineering of nanopreparations with functional moieties to facilitate prolonged circulation, targetability, enhanced intracellular penetration, and stimuli-sensitivity. The particular characteristics of the tumor microenviroment, such as reduced pH, increased local temperature, and altered redox status, provide guidelines for design of stimuli-sensitive drug delivery systems that respond to these specific differences. Another important goal for stimuli-sensitive drug delivery systems is avoidance of multidrug resistance, which is one of the most important causes of ineffective chemotherapy.