Cassia tora Linn.: A boon to Alzheimer's disease for its anti-amyloidogenic and cholinergic activities


Chethana K. R. , ŞENOL DENİZ F. S. , ERDOĞAN ORHAN İ. , Anilakumar K. R. , Keri R. S.

PHYTOMEDICINE, cilt.33, ss.43-52, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.phymed.2017.06.002
  • Dergi Adı: PHYTOMEDICINE
  • Sayfa Sayıları: ss.43-52

Özet

Background: Drug discovery from natural products as alternatives for Alzheimer's disease (AD) is a current trend. For which plant is an alternative for searching potential molecule for treating AD. Availability of Cassia tora as weed and abundance in nature makes it as potential source. Many plants group under Leguminosae family has potential medicinal property of which Cassia tora is an appropriate choice, to know potency against AD. Etiology of AD is described by senile plaques and neurofibrillary tangles. The A beta(42) has key major role in forming plaques by forming structures like protobirils, oligomers and final fibrilar like structures. Even at in vitro conditions, the peptides have a fibrilar like structure, which was exploited to preliminary screening of natural sources that may be effective in treating AD.