Akademik Veri Yönetim Sistemi
37th European Congress of Pathology, Vienna, Avusturya, 06 Eylül 2025, cilt.487, ss.1-563, (Özet Bildiri)
E-PS-24-015
Clinicopathological analysis of solitary fibrous tumour patients: a single-center study
H.İ. Saribiyik¹, A.H. Üstündağ², G. Esendagli¹
¹ Gazi University Faculty of Medicine, Pathology, Ankara, Turkey, ² Gazi University Faculty of Dentistry, Department of Oral Pathology, Ankara, Turkey
Background & Objectives: Solitary fibrous tumour (SFT) is a rare mesenchymal neoplasm that can exhibit diverse biological behaviour. Identifying prognostic factors is crucial for risk stratification and clinical management. This study aims to evaluate the relationship between tumour necrosis, mitotic activity, tumour size, gender, recurrence and metastasis in patients diagnosed with SFT.
Methods: We retrospectively analysed 83 SFT patients with documented data on tumour size, mitotic count, necrosis, grade, recurrence, metastasis and survival. Statistical correlations were assessed between pathological features and clinical outcomes. All cases re-evaluated by two pathologists.
Results: The mean age was 54.9 years (16-77). Gender and location differences were analysed, but no statistically significant impact on prognosis was observed. Among the patients, 20% developed recurrence, and 8.7% experienced metastasis. The presence of necrosis increased the risk of metastasis by 6.2 times (p-value: 0.008). Mitotic count was found to be one of the strongest predictive indicators of recurrence (p < 0.001) and metastasis (p = 0.003). Tumours over 15 cm alone carry a 40% risk of metastasis (p = 0.026). The four-variable model showed that high-risk patients had the highest recurrence rate (31.3%). The three-variable model also indicated high recurrence risk, but less prominently than the four-variable model. In terms of metastasis, the three-variable model showed that high-grade patients had a higher risk (p = 0.09). The four-variable model indicated that both intermediate and high- risk groups were at increased risk of metastasis, though not as distinctly as the three-variable model. Conclusion: Mitotic activity, tumour necrosis and size appear to be key prognostic indicators in SFT. These findings highlight the importance of comprehensive histopathological evaluation in predicting patient outcomes and follow-up. Further large-scale studies are needed to validate these results and refine risk assessment strategies for SFT patients.