SERUM BETA-CAROTENE, VITAMIN-E, VITAMIN-C AND MALONDIALDEHYDE LEVELS IN SEVERAL TYPES OF CANCER


TORUN M., YARDIM S. , GONENC A. , SARGIN H., MENEVSE A., SIMSEK B.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, vol.20, no.5, pp.259-263, 1995 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 5
  • Publication Date: 1995
  • Doi Number: 10.1111/j.1365-2710.1995.tb00660.x
  • Title of Journal : JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
  • Page Numbers: pp.259-263

Abstract

We measured the levels of serum carotenoids (beta-carotene), total tocopherol (vitamin E), ascorbic acid and malondialdehyde (MDA) in newly diagnosed cancer cases. Levels of the antioxidants and MDA in serum samples from 208 subjects with cancer affecting different sites (59 breast, 38 head and neck, 46 genitourinary, 12 lung, 20 gastrointestinal and 33 other sites) were compared with levels in 156 controls. Cases and controls were compared with respect to a number of potentially confounding factors: age, sex, smoking status, Quetelet index (kg/m(2)), diet and alcohol intake. Mean (+/- SD) levels of beta-carotene, vitamin E and vitamin C were significantly lower among the cases than the controls (49.35 +/- 36.55 mu g/l, 0.60 +/- 0.14 mg/dl, 0.40 +/- 0.27 mg/dl and 75.31 +/- 28.59 mg/dl, 0.98 +/- 0.13 mg/dl, 0.88 +/- 0.47 mg/dl, respectively) (P<0.05).