Spectroscopic studies on the interactions of 5-ethyl-6-phenyl-3,8-bis((3-aminoalkyl)propanamido)phenanthridin-5-ium derivatives with G-quadruplex DNA


Yalcin E., Duyar H., Ihmels H., Seferoglu Z.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, cilt.196, ss.432-438, 2018 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 196
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.saa.2018.02.051
  • Dergi Adı: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
  • Sayfa Sayıları: ss.432-438

Özet

© 2018 Elsevier B.V.An improved microwave-induced synthesis of five ethidium derivatives (Ethidium derivatives, 2a–d) is presented. As the derivatives 2a–d have been proposed previously to be telomerase inhibitors, the binding interactions of these ethidium derivatives with G-quadruplex DNA were evaluated by means of photometric and fluorimetric titration, thermal DNA denaturation, CD and 1H NMR spectroscopy. In particular, the compound bearing 3,8-bis(pyrrolidin-1-yl)propanamido substituent 2a exhibits high selectivity for G-quadruplex DNA relative to duplex DNA.