Effect of Montelukast on Spinal Cord Ischemia-Reperfusion Injury

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Korkmaz K., Gedik H. S., Budak A. B., Yener A. U., Kaya E., Genc S. B., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.25, sa.5, ss.757-765, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5137/1019-5149.jtn.11499-14.2
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.757-765
  • Anahtar Kelimeler: Spinal cord ischemia, Montelukast, Reperfusion injury, Rat, Experimental, CysLT1 receptor, ISCHEMIA/REPERFUSION INJURY, INDUCED APOPTOSIS, N-ACETYLCYSTEINE, RATS, LEUKOTRIENES, PROTECTION, NEUROPROTECTION, MECHANISMS, MEDIATORS, ILOPROST
  • Gazi Üniversitesi Adresli: Hayır

Özet

AIM: Paraplegia due to ischemia-reperfusion (I/R) injury of the spinal cord is a devastating complication of thoracoabdominal aortic surgery. Cysteinyl leukotrienes are potent mediators of inflammation that are associated with I/R injury. The present study was designed to investigate the role of montelukast, a selective reversible CysLT1 receptor antagonist, on spinal cord I/R injury in an experimental model.