Effect of Montelukast on Spinal Cord Ischemia-Reperfusion Injury


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Korkmaz K., Gedik H. S. , Budak A. B. , Yener A. U. , Kaya E., Genc S. B. , ...More

TURKISH NEUROSURGERY, vol.25, no.5, pp.757-765, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.5137/1019-5149.jtn.11499-14.2
  • Title of Journal : TURKISH NEUROSURGERY
  • Page Numbers: pp.757-765

Abstract

AIM: Paraplegia due to ischemia-reperfusion (I/R) injury of the spinal cord is a devastating complication of thoracoabdominal aortic surgery. Cysteinyl leukotrienes are potent mediators of inflammation that are associated with I/R injury. The present study was designed to investigate the role of montelukast, a selective reversible CysLT1 receptor antagonist, on spinal cord I/R injury in an experimental model.