The correlation between EBV viral load in the palatine tonsils of patients with recurrent tonsillitis and concurrent serum titers of VCA-IgG

Dogan B., Rota S., Gurbuzler L., BOZDAYI G., Ceyhan M. N. , Inal E.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, vol.267, no.1, pp.143-148, 2010 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 267 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1007/s00405-009-0988-6
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.143-148


Epstein-Barr virus (EBV) infection usually occurs in early childhood and can persist in palatine tonsil lymphocytes to induce tonsillitis at a later date. We have examined the presence of EBV in palatine tonsils and relationship between EBV-DNA quantity in tonsil tissues and VCA-IgG quantity in autologous sera. Tonsils were obtained from 36 patients, male 20 (55.6%), female 16 (44.4%) (mean age 7.96 +/- A 6.97 years), who underwent tonsils removal because of recurrent tonsillitis. Tissues were processed for real-time PCR and patient's sera were assayed to determine VCA-IgG by VCA-IgG ELISA. In 27 out of 36 cases (75%), positive EBV-DNA reaction was found. However, statistical analysis showed no correlation between EBV-DNA quantity and VCA-IgG quantity. We conclude that tonsils of children can be colonized by EBV and that virus may have a direct and indirect role in recurrent tonsillitis and nasopharyngeal carcinoma.