Prevention by a carbacyclin analogue (ZK 36 374) of digoxin-induced ventricular extrasystoles in guinea-pig myocardium

Metin M., Dörtlemez Ö., Akar F., Ercan Z., Türker R.

European Journal of Pharmacology, cilt.98, sa.1, ss.125-128, 1984 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98 Sayı: 1
  • Basım Tarihi: 1984
  • Doi Numarası: 10.1016/0014-2999(84)90117-1
  • Dergi Adı: European Journal of Pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.125-128
  • Anahtar Kelimeler: Digoxin, P-R intervel, Venticular extrasystoles, ZK 36 374
  • Gazi Üniversitesi Adresli: Evet

Özet

Intravenous infusion of ZK 36 374 to the anesthized guinea-pig or addition of the compound to the perfusion medium of the isolated perfused guinea-pig heart prevented digoxin-induced ventricular premature beats without altering the prolongation of the P-R interval by the glycoside. The prevention by ZK 36 374 of the ventricular extrasystoles induced by digoxin was obtained at lower concentrations while higher doses of the compound produced a dysrhythmic effect which terminated within a few min after the cessation of drug application. © 1984.