Prevention by a carbacyclin analogue (ZK 36 374) of digoxin-induced ventricular extrasystoles in guinea-pig myocardium
European Journal of Pharmacology, cilt.98, sa.1, ss.125-128, 1984 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 98 Sayı: 1
- Basım Tarihi: 1984
- Doi Numarası: 10.1016/0014-2999(84)90117-1
- Dergi Adı: European Journal of Pharmacology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
- Sayfa Sayıları: ss.125-128
- Anahtar Kelimeler: Digoxin, P-R intervel, Venticular extrasystoles, ZK 36 374
- Gazi Üniversitesi Adresli: Evet
Özet
Intravenous infusion of ZK 36 374 to the anesthized guinea-pig or addition of the compound to the perfusion medium of the isolated perfused guinea-pig heart prevented digoxin-induced ventricular premature beats without altering the prolongation of the P-R interval by the glycoside. The prevention by ZK 36 374 of the ventricular extrasystoles induced by digoxin was obtained at lower concentrations while higher doses of the compound produced a dysrhythmic effect which terminated within a few min after the cessation of drug application. © 1984.