Plant-Derived Natural Compounds for the Treatment of Amyotrophic Lateral Sclerosis: An Update


Mohi-ud-Din R., Mir R. H. , Shah A. J. , Sabreen S., Wani T. U. , Masoodi M. H. , ...More

CURRENT NEUROPHARMACOLOGY, vol.20, no.1, pp.179-193, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 20 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.2174/1570159x19666210428120514
  • Journal Name: CURRENT NEUROPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE, Psycinfo
  • Page Numbers: pp.179-193
  • Keywords: Plant-derived products, SOD1 mutations, CNS disorders, SAR, clinical trials, Therapeutic effects, TRANSGENIC MOUSE MODEL, RAT CORTICAL-NEURONS, SPINAL-CORD-INJURY, OXIDATIVE STRESS, PC12 CELLS, NEURODEGENERATIVE DISEASES, INDUCED NEUROTOXICITY, EPIGALLOCATECHIN-GALLATE, NEUROPROTECTIVE AGENTS, SIGNALING PATHWAYS

Abstract

Background: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease (MND) that typically causes death within 3-5 years after diagnosis. Regardless of the substantial scientific knowledge accrued more than a century ago, truly effective therapeutic strategies remain distant. Various conventional drugs are being used but are having several adverse effects. Objective/Aim: The current study aims to thoroughly review plant-derived compounds with well-defined ALS activities and their structure-activity relationships. Moreover, the review also focuses on complex genetics, clinical trials, and the use of natural products that might decrypt the future and novel therapeutics in ALS. Methods: The collection of data for the compilation of this review work was searched in PubMed Scopus, Google Scholar, and Science Direct. Results: Results showed that phytochemicals like-Ginkgolides, Protopanaxatriol, Genistein, epigal-locatechingallate, resveratrol, cassoside, and others possess Amyotrophic lateral sclerosis (ALS) ac-tivity by various mechanisms . Conclusion: These plant-derived compounds may be considered as supplements for conventional (ALS). Moreover, further preclinical and clinical studies are required to understand the structure-and mechanisms of natural