Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: Lack of association with clinical phenotypes

Kocabas, Neslihan; Antonijevic, Irina; Faghel, Carole; Forray, Carlos; Kasper, Siegfried; Lecrubier, Yves; Linotte, Sylvie; Massat, Isabelle; Montgomery, Stuart; Noro, Magali; Oswald, Pierre; Snyder, Lenore; Souery, Daniel; Zohar, Joseph; Mendlewicz, Julien

doi:10.3109/15622975.2010.512089

Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: Lack of association with clinical phenotypes

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Kocabas N. A., Antonijevic I., Faghel C., Forray C., Kasper S., Lecrubier Y., ...More

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, vol.11, no.8, pp.985-990, 2010 (SCI-Expanded)

Publication Type: Article / Article
Volume: 11 Issue: 8
Publication Date: 2010
Doi Number: 10.3109/15622975.2010.512089
Journal Name: WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.985-990
Gazi University Affiliated: No

Abstract

Objectives. Dystrobrevin binding protein 1 (Dysbindin) is a plausible candidate gene for major depressive disorders (MDD) due to its involvement in synaptic signaling, plasticity and localization in the brain. Methods. Two intronic SNPs of DTNBP1; rs760761 (P1320) and rs2619522 (P1763) were analyzed in 206 patients with DSM-IV MDD to investigate the functional impact of genotypes on susceptibility for depression and some clinical phenotypes. The Sequenom iPLEX assay (Sequenom, Cambridge, MA) was used for genotyping. Results and Conclusions. Despite the limited power of analysis, our results showed that these two SNPs in DTNPB1 gene were not related to clinical phenotypes such as melancholia, age at onset, suicidality and co-morbid anxiety disorders, as well as to treatment response phenotypes.