Mu-opioid receptor binding measured by [C-11]carfentanil positron emission tomography is related to craving and mood in alcohol dependence


Bencherif B., Wand G., McCaul M., Kim Y., Iigin N. , Dannals R., ...More

BIOLOGICAL PSYCHIATRY, vol.55, no.3, pp.255-262, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1016/j.biopsych.2003.07.007
  • Title of Journal : BIOLOGICAL PSYCHIATRY
  • Page Numbers: pp.255-262
  • Keywords: Mu opioid receptors, alcoholism, craving, depression, PET imaging, COMPULSIVE DRINKING SCALE, BRAIN METABOLIC-CHANGES, FAMILY-HISTORY, ETHANOL-CONSUMPTION, BETA-ENDORPHIN, PSYCHOMETRIC PROPERTIES, NALTREXONE, RATS, NALOXONE, PREFERENCE

Abstract

Background: The endogenous opioid system has been linked to alcohol dependence through animal and human studies. We investigated the relationship between alcohol craving and brain mu opioid receptors (R-OR) in alcohol-dependent subjects.