Mu-opioid receptor binding measured by [C-11]carfentanil positron emission tomography is related to craving and mood in alcohol dependence

Bencherif B., Wand G., McCaul M., Kim Y., Iigin N., Dannals R., ...More

BIOLOGICAL PSYCHIATRY, vol.55, no.3, pp.255-262, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1016/j.biopsych.2003.07.007
  • Journal Name: BIOLOGICAL PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.255-262
  • Keywords: Mu opioid receptors, alcoholism, craving, depression, PET imaging, COMPULSIVE DRINKING SCALE, BRAIN METABOLIC-CHANGES, FAMILY-HISTORY, ETHANOL-CONSUMPTION, BETA-ENDORPHIN, PSYCHOMETRIC PROPERTIES, NALTREXONE, RATS, NALOXONE, PREFERENCE
  • Gazi University Affiliated: Yes

Abstract

Background: The endogenous opioid system has been linked to alcohol dependence through animal and human studies. We investigated the relationship between alcohol craving and brain mu opioid receptors (R-OR) in alcohol-dependent subjects.