Mitomycin C prevents strictures in caustic esophageal burns in rats


Turkyilmaz Z., Sonmez K., Demirtola A., Karabulut R., Poyraz A., Gulen S., ...More

JOURNAL OF SURGICAL RESEARCH, vol.123, no.2, pp.182-187, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 123 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1006/j.jss.2004.08.009
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.182-187
  • Keywords: mitomycin C, caustic esophageal strictures, prevention, LYE STRICTURES, CORROSIVE ESOPHAGITIS, MORPHOLOGIC ASPECTS, CHILDREN, SURGERY, PENTOXIFYLLINE, INHIBITION, INJURIES, COLLAGEN, FIBROSIS
  • Gazi University Affiliated: Yes

Abstract

Background. Caustic esophageal. injuries lead to stricture formation. Although a number of agents have been tried experimentally to prevent strictures, few have gained clinical application. The purpose of this study was to investigate the effectiveness of Mitomycin C (MMC), which inhibits fibroblastic proliferation in preventing caustic esophageal strictures.