The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

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Salehi B., Sharifi-Rad J., Cappellini F., Reiner Z., Zorzan D., Imran M., ...More

FRONTIERS IN PHARMACOLOGY, vol.11, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 11
  • Publication Date: 2020
  • Doi Number: 10.3389/fphar.2020.01300
  • Keywords: anthocyanins, biodisponibility, neuroprotective, cardioprotective, antiobesity, antidiabetic, antioxidant, anticancer, HIGH-FAT-DIET, INDUCED OXIDATIVE STRESS, CARDIOVASCULAR-DISEASE MORTALITY, ACTIVATED PROTEIN-KINASE, C-REACTIVE PROTEIN, ORYZA-SATIVA L., CELLS IN-VITRO, NF-KAPPA-B, INSULIN-RESISTANCE, SIGNALING PATHWAYS


Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and antiinflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in cardiovascular and neuroprotective prevention. This review aims to comprehensively analyze different studies performed on this class of compounds, their bioavailability and their therapeutic potential. An in-depth look in preclinical,in vitroandin vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects.