Carboplatin and oral cyclophosphamide combination after temozolomide failure in malignant gliomas


Yaman E., Buyukberber S., ÜNER A. , Coskun U., Yamac D., Ozturk B., ...Daha Fazla

TUMORI J, cilt.94, sa.5, ss.674-680, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 94 Konu: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1177/030089160809400505
  • Dergi Adı: TUMORI J
  • Sayfa Sayıları: ss.674-680

Özet

Background. Temozolomide is a novel cytotoxic agent for malignant gliomas. However, treatment failure Occurs approximately in half of patients, and the optimal regimen in this setting has yet to be defined. In the present study, we assessed retrospectively the efficacy and toxicity of the combination of carboplatin and oral cyclophosphamide in temozolomide-resistant patients.