Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study

CİNDORUK, MEHMET; KEREM, MUSTAFA; KARAKAN, TARKAN; Salman, Bulent; Akin, Okan; Alper, Murat; ERDEM, OSMAN; Uenal, Selahattin

doi:10.1186/1471-230x-7-44

Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study

CİNDORUK M., KEREM M., KARAKAN T., Salman B., Akin O., Alper M., ...Daha Fazla

BMC GASTROENTEROLOGY, cilt.7, 2007 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 7
Basım Tarihi: 2007
Doi Numarası: 10.1186/1471-230x-7-44
Dergi Adı: BMC GASTROENTEROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Gazi Üniversitesi Adresli: Evet

Özet

Background: Peroxisome proliferators-activated receptor alpha ( PPAR alpha) activation modulates cholesterol metabolism and suppresses bile acid synthesis. This study aims to evaluate the effect of short-term administration of fenofibrate, a PPAR alpha agonist, on proinflammatory cytokines, apoptosis, and hepatocellular damage in cholestasis.