Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study

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CİNDORUK M., KEREM M., KARAKAN T., Salman B., Akin O., Alper M., ...Daha Fazla

BMC GASTROENTEROLOGY, cilt.7, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1186/1471-230x-7-44
  • Dergi Adı: BMC GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Peroxisome proliferators-activated receptor alpha ( PPAR alpha) activation modulates cholesterol metabolism and suppresses bile acid synthesis. This study aims to evaluate the effect of short-term administration of fenofibrate, a PPAR alpha agonist, on proinflammatory cytokines, apoptosis, and hepatocellular damage in cholestasis.