INFLUENCE OF NOCLOPROST ON THE VASCULAR-RESPONSES TO VARIOUS STIMULI IN THE ISOLATED PERFUSED RABBIT KIDNEY


ERCAN Z., TURKER R.

EXPERIENTIA, vol.47, no.1, pp.69-70, 1991 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 1
  • Publication Date: 1991
  • Doi Number: 10.1007/bf02041256
  • Journal Name: EXPERIENTIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA)
  • Page Numbers: pp.69-70
  • Gazi University Affiliated: No

Abstract

Nocloprost, a new synthetic prostanoid, elicited a vasodilator action when given through the renal artery of the isolated perfused rabbit kidney. Lower concentrations of the compound inhibited the pressor response to sympathetic stimulation or to angiotensin II, but potentiated the pressor effect of exogenous noradrenaline. These results were taken as an evidence that nocloprost prevents the release of neurotransmitter by a presynaptic mechanism.