Objective: The launch of new generation antipsychotics in 1990 impacting the prescription trends all over the world. The aim of this study was to evaluate trends and patterns regarding antipsychotic prescription on inpatient and outpatient basis at a university clinic. Method: Study period encompassed the years 1996-2005. A total of 34120 records were reached and retrospectively evaluated. Those who had been prescribed antipsychotic medicine of any kind were chosen for the study group (n=2868). Patients' socio-demografic characteristics, diagnosis, the first choice antipsychotic, and were included determined the switch of first antipsychotic and the reasons for that switch. Results: Prescription of conventional antipsychotics has been decreased dramatically within the study period (89.8%-15.5%) where the new generation antipsyhotics were introduced. The most commonly used new generation antipsychotics were risperidone (38.7%), olanzapine (22.4%) and clozapine (19.8%). While new generation antipsychotics stand for chronic psychosis like schizophrenia (58.2%), conventional ones stand for affective psychosis (56.8%). Antipsychoticswitch was not made for 70.3% of clasical antipsychotics and 85.9% of new generation antipsychotics during the study period. The most common reason for antipsychotic switch was lack of efficacy for both clasical and new generation antipsychotics (35.3%). Conclusion: Study period indicates a major shift in prescription patterns. Dominating preference of new generation antipsychotics seem to be the case for that shift in question. Rate of antipsychotic switch was low for both groups, but more switch was made for classical antipsychotics.