Cyanotoxin genotoxicity: a review

YILMAZ S., Ulger T. G., GÖKTAŞ B., Ozturk S., Karatas D. O., BEYZİ E.

TOXIN REVIEWS, cilt.41, sa.2, ss.699-712, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 41 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/15569543.2021.1922922
  • Dergi Adı: TOXIN REVIEWS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, BIOSIS, CAB Abstracts, EMBASE, Environment Index, Food Science & Technology Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.699-712
  • Anahtar Kelimeler: Cyanobacteria, cyanotoxin, Cylindrospermopsin, Microcystin, Nodularin, Anatoxin-a, Homoanatoxin-a, toxicity, genotoxicity, INDUCED DNA-DAMAGE, CULTURED RAT HEPATOCYTES, MICROCYSTIN-LR EXPOSURE, CYANOBACTERIAL TOXIN, IN-VIVO, OXIDATIVE STRESS, DRINKING-WATER, ANATOXIN-A, CELL-LINES, PROMOTES MIGRATION
  • Gazi Üniversitesi Adresli: Evet

Özet

Cyanobacteria are broadly producing secondary metabolites including cyanotoxins. More than 40 genera of cyanobacteria produce cyanotoxins. The presence of cyanotoxins in water presents a global problem due to environmental deterioration and possible toxic effects to human and animals. Because of anthropogenic activities and climate change, the occurrence of these toxins have been increasing worldwide. The major route of human exposure to cyanotoxins is the oral intake. Increased exposure of cyanotoxins brings some risks related to public health. In this review, possible genotoxic effects of well-known cyanotoxins (Cylindrospermopsin, Microcystin-LR, Nodularin, Anatoxin-a and Homoanatoxin-a) were deeply reviewed. This article aimed to explain genotoxic activity and mechanisms underlying the genotoxic effects of cyanotoxins by reviewing large databases.