Effect of polylactide/glycolide (PLGA) membranes loaded with metronidazole on periodontal regeneration following guided tissue regeneration in dogs.

Kurtis B. , Unsal B. , Cetiner D., Gultekin E. , Ozcan G., Celebi N., ...More

Journal of periodontology, vol.73, no.7, pp.694-700, 2002 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 7
  • Publication Date: 2002
  • Doi Number: 10.1902/jop.2002.73.7.694
  • Title of Journal : Journal of periodontology
  • Page Numbers: pp.694-700


Background: Bioabsorbable membranes have been successfully used for guided tissue regeneration (GTR) and local delivery systems because they are biocompatible and do not require second surgery for removal. Several studies have demonstrated that metronidazole, when applied topically, produced immediate effects on microbiological and clinical parameters, most notably a reduction in probing depth and loss of attachment. The purpose of this study was to evaluate the regenerative potential of a metronidazole-loaded biodegradable (polylactide/glycolide) (PLGA) GTR membrane in dogs.