The Relationship between Pre-Infarction Angina and Serum Sphingosine-1-Phosphate Levels

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Kiziltunc E., ABACI A., Ozkan S., Alsancak Y., Unlu S., Elbeg S., ...More

ACTA CARDIOLOGICA SINICA, vol.30, no.6, pp.546-552, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.6515/acs20140310a
  • Journal Name: ACTA CARDIOLOGICA SINICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.546-552
  • Keywords: Ischemic preconditioning, Pre-infarction angina, Sphingosine 1 phosphate, CORONARY-ARTERY-DISEASE, SPHINGOSINE 1-PHOSPHATE, MYOCARDIAL-INFARCTION, CELL INJURY, PLASMA, MECHANISM, HEART, PRETREATMENT, ADENOSINE, ISCHEMIA
  • Gazi University Affiliated: Yes

Abstract

Background: Pre-infarction angina reduces myocardial infarct size by preventing the myocardium from being subjected to ischemia reperfusion (I/R) injury. Ischemic preconditioning is the proposed mechanism for this effect. Sphingosine 1 phosphate (S1P) activates ischemic preconditioning pathways and may play a role in the presence of cardioprotective effects of pre-infarction angina. Therefore, we evaluated the relationship between pre-infarction angina and serum S1P levels.