Mechanisms of motor dysfunction after transient MCA occlusion - Persistent transmission failure in cortical synapses is a major determinant


Bolay H. B. , Dalkara T.

STROKE, vol.29, no.9, pp.1988-1993, 1998 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 9
  • Publication Date: 1998
  • Doi Number: 10.1161/01.str.29.9.1988
  • Title of Journal : STROKE
  • Page Numbers: pp.1988-1993
  • Keywords: cerebral ischemia, focal, penumbra, ischemic, motor cortex, evoked potentials, transmission, synaptic, MIDDLE CEREBRAL-ARTERY, SOMATOSENSORY EVOKED-POTENTIALS, BLOOD-FLOW, FUNCTIONAL RECOVERY, BRAIN EDEMA, ISCHEMIA, CORTEX, RAT, THRESHOLDS, DIASCHISIS

Abstract

Background and Purpose-Failure of prompt motor recovery after spontaneous recirculation or thrombolytic therapy may be due to an unsatisfactory restoration of synaptic activity within cortex and/or blockade of electrical impulses at the severely ischemic subcortical region.