Extrathoracic airway responsiveness in children with asthma-like symptoms, including chronic persistent cough

Turktas I., Dalgic N., Bostanci I., Cengizlier R.

PEDIATRIC PULMONOLOGY, vol.34, no.3, pp.172-180, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2002
  • Doi Number: 10.1002/ppul.10077
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.172-180
  • Gazi University Affiliated: No


Asthma-like symptoms, including chronic persistent cough, are not always specific for classical asthma. In order to investigate whether assessment of extrathoracic airway hyperresponsiveness (EAHR) during methacholine bronchial challenge helped in the evaluation of pediatric patients with asthma-like symptoms such as chronic cough, we examined 133 consecutive, unselected patients (mean age, 10.06 +/- 2.16 years) who had neither established asthma nor bronchial obstruction previously. We recorded the forced mid-inspiratory flow (FIF50) as an index of extrathoracic airway narrowing. In addition, a 25% decrease in FIF50 (PD25FIF50) below the cutoff concentration of less than or equal to 8 mg/mL methacholine was assumed to indicate EAHR.