The effect of ethyl pyruvate on oxidative stress in intestine and bacterial translocation after thermal injury

Karabeyoglu, Melih; Unal, Bulent; Bozkurt, Betuel; Dolapci, Istar; Bilgihan, Ayse; Karabeyoglu, Isil; Cengiz, Oemer

doi:10.1016/j.jss.2007.02.050

The effect of ethyl pyruvate on oxidative stress in intestine and bacterial translocation after thermal injury

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Karabeyoglu M., Unal B., Bozkurt B., Dolapci I., Bilgihan A., Karabeyoglu I., ...More

JOURNAL OF SURGICAL RESEARCH, vol.144, no.1, pp.59-63, 2008 (SCI-Expanded)

Publication Type: Article / Article
Volume: 144 Issue: 1
Publication Date: 2008
Doi Number: 10.1016/j.jss.2007.02.050
Journal Name: JOURNAL OF SURGICAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.59-63
Keywords: intestinal mucosal barrier, thermal injury, ethyl pyruvate, bacterial translocation, ISCHEMIA-REPERFUSION INJURY, ISCHEMIA/REPERFUSION INJURY, LIPID-PEROXIDATION, ORGAN DAMAGE, RAT MODEL, MICE, SEPSIS, INFLAMMATION, FAILURE, CELLS
Gazi University Affiliated: Yes

Abstract

Background. Thermal injury causes a breakdown in the intestinal mucosal barrier due to ischemia reperfusion injury, which can induce bacterial translocation (BT), sepsis, and multiple organ failure in burn patients. The aim of this study was to investigate the effect of ethyl pyruvate (EP) on intestinal oxidant damage and BT in burn injury.