We evaluated the effects of three different surface treatments and two different bonding procedures on shear bond strength of resin composites to different computer-aided design/manufacturing (CAD/CAM) ceramics with or without thermocycling. The test specimens were prepared from three different CAD/CAM ceramics (Group A, IPS e.max CAD; Group B, IPS e.max ZirCAD; Group C, Vita Suprinity). They were divided into eight subgroups according to the surface treatment and bonding procedures. After resin composite was applied to the surfaces of all test specimens, they were stored in distilled water for 24 h at 37 degrees C. Next, half of the test specimens were subjected to a thermocycling procedure, and the other half were stored in distilled water at 37 degrees C throughout thermocycling. The shear bond strength was performed using a universal testing machine. Statistical analysis revealed that the ceramic types (P > 0.0031) and thermocycling (P > 0.0021) did not, but the surface treatment technique did significantly affect the shear bond strength values (P < 0.05; except group C). Higher bond strength values were observed with HF etching in Groups A and C compared with the other tested surface treatments.