DIFFERENTIAL-PULSE POLAROGRAPHIC-DETERMINATION OF DITHRANOL FROM CREAM PHARMACEUTICAL PREPARATION


TEMIZER A., OZER D., ORBEY M.

ANALYTICAL LETTERS, cilt.27, sa.4, ss.717-722, 1994 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 27 Konu: 4
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1080/00032719408000265
  • Dergi Adı: ANALYTICAL LETTERS
  • Sayfa Sayıları: ss.717-722

Özet

A method has been developed to analyze dithranol by using differential pulse polarography. The method developed was applied to a cream pharmaceutical preparation and compared with an official method. Electroanalytical studies show that a peak at -1.78 V vs. Ag/AgCl reference electrode in 0.05 M Et(4)NI solution can be used for the analysis of dithranol in the range of 0.2-6.5 ppb. A method for the analysis of dithranol has been applied to a cream pharmaceutical preparation after an extraction procedure. The liquid-liquid extraction has been accomplished by using chloroform. The recovery has been found to be 98% with a relative standard deviation of 2.70%.