The effects of propofol or halothane on free radical production after tourniquet induced ischaemia-reperfusion injury during knee arthroplasty


Aldemir O., Celebi H., Cevik C., Duzgun E.

ACTA ANAESTHESIOLOGICA SCANDINAVICA, vol.45, no.10, pp.1221-1225, 2001 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 10
  • Publication Date: 2001
  • Doi Number: 10.1034/j.1399-6576.2001.451008.x
  • Journal Name: ACTA ANAESTHESIOLOGICA SCANDINAVICA
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1221-1225
  • Keywords: propofol, halothane, knee arthroplasty, antioxidant activity, malondialdehyde, ISOLATED RAT-HEART, ISCHEMIA-REPERFUSION, LIPID-PEROXIDATION, REGIONAL ISCHEMIA, XANTHINE-OXIDASE, LIVER-MICROSOMES, HUMAN-DISEASE, IN-VIVO, RELEASE, MITOCHONDRIA

Abstract

Background: Ischaemia-reperfusion injury following tourniquet release is a good in vivo model for evaluating acute conditions. The aim of the study was to investigate the effects of propofol or halothane anaesthesia on oxidative stress by determining malondialdehyde (MDA) levels during knee arthroplasty.