Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study

APAYDIN F. G., Kaltalioglu K., Balabanli B., COŞKUN CEVHER Ş.

GAZI UNIVERSITY JOURNAL OF SCIENCE, cilt.31, sa.2, ss.399-406, 2018 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 2
  • Basım Tarihi: 2018
  • Dergi Adı: GAZI UNIVERSITY JOURNAL OF SCIENCE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.399-406
  • Anahtar Kelimeler: Cisplatin, Hepatotoxicity, Hesperidin, Histopathology, Morin, Nephrotoxicity, OXIDATIVE STRESS, TOXICITY, LIVER, MECHANISMS, PREVENTION, KIDNEY
  • Gazi Üniversitesi Adresli: Evet

Özet

In this study, we investigated that the histopathological changes of rat kidney and liver tissues after cisplatin administration and potential beneficial effects of morin and hesperidin administration. Wistar rats were randomly divided in 7 groups: control, morin (M), hesperidin (H), cisplatin (CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H), cisplatin+morin+hesperidin (CP+M+H). Kidney and liver tissues were collected at the end of the experiment and were evaluated histopathological changes. Various histopathological changes in kidney and liver tissues of cisplatin-induced group were revealed. However, pre- and co-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxic changes in cisplatin-induced groups.