Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study


APAYDIN F. G. , Kaltalioglu K., Balabanli B., COŞKUN CEVHER Ş.

GAZI UNIVERSITY JOURNAL OF SCIENCE, vol.31, no.2, pp.399-406, 2018 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 2
  • Publication Date: 2018
  • Title of Journal : GAZI UNIVERSITY JOURNAL OF SCIENCE
  • Page Numbers: pp.399-406
  • Keywords: Cisplatin, Hepatotoxicity, Hesperidin, Histopathology, Morin, Nephrotoxicity, OXIDATIVE STRESS, TOXICITY, LIVER, MECHANISMS, PREVENTION, KIDNEY

Abstract

In this study, we investigated that the histopathological changes of rat kidney and liver tissues after cisplatin administration and potential beneficial effects of morin and hesperidin administration. Wistar rats were randomly divided in 7 groups: control, morin (M), hesperidin (H), cisplatin (CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H), cisplatin+morin+hesperidin (CP+M+H). Kidney and liver tissues were collected at the end of the experiment and were evaluated histopathological changes. Various histopathological changes in kidney and liver tissues of cisplatin-induced group were revealed. However, pre- and co-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxic changes in cisplatin-induced groups.